Diabetes 2 stress
University of Texas Health Science Center at San Antonio Summary: A hormone with anti-diabetic properties also diabetes 2 stress depression-like symptoms in mice. The finding offers a novel diabetes 2 stress for treating depression.
The hormone, called adiponectin, is secreted by adipose tissue and sensitizes the body to the action of insulin, a hormone that lowers blood sugar. Lu said.
Facing Goliath over and over In the study mice were exposed to 14 days of repeated social defeat stress. Each male mouse was introduced to the home cage of an unfamiliar, aggressive resident mouse for 10 minutes and physically defeated.
After the defeat, the resident mouse and the intruder mouse each were housed in half of the cage separated by a perforated plastic divider to allow visual, olfactory and auditory contact for the remainder of the hour period. Mice were exposed to a new resident mouse cage and subjected to social defeat each day.
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Plasma adiponectin concentrations were determined after the last social defeat session. Defeated mice displayed lower plasma adiponectin levels.
Withdrawal, lost pleasure and helplessness When adiponectin concentrations were reduced diabetes 2 stress deleting one allele of the adiponectin gene or by a neutralizing antibody, mice were more susceptible to stress-induced social withdrawal, anhedonia lost capacity to experience pleasure and learned helplessness. Mice that were fed a high-fat diet 60 percent calories from fat for 16 weeks developed obesity and type 2 diabetes.
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Administration of adiponectin to these mice and mice of normal weight produced antidepressant-like effects. Possible innovative approach for depression "These findings suggest a critical role of adiponectin in the development of depressive-like behaviors and may lead to an innovative therapeutic approach to fight depression," Dr.
A novel approach would benefit thousands. Unfortunately, the use of current antidepressants can worsen the control of diabetic patients.
Adiponectin, with its anti-diabetic activity, would serve as an innovative therapeutic target for depression treatments, especially for those individuals with diabetes or prediabetes and perhaps those who fail to respond to currently available antidepressants.
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Int J Mol Sci.
Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity.